Impact of the Adverse Social Exposome on Survival in Individuals With Amyotrophic Lateral Sclerosis

Key points

Paper examining the investigation into the association between adverse social exposome and development of ALS

screenshot of the first two pages of a scientific paper

Affiliates

Dae-Gyu Jang[1][2], Amy J. Kind[3][4], Adam Patterson[1][2], Meredith Pedde[5], W. Ryan Powell[3][4], Eva L. Feldman[1][2], and Stephen A. Goutman[1][2]

  1. Department of Neurology, University of Michigan, Ann Arbor
  2. NeuroNetwork for Emerging Therapies, University of Michigan, Ann Arbor
  3. Center for Health Disparities Research, University of Wisconsin School of Medicine and Public Health, Madison
  4. Division of Geriatrics and Gerontology, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison
  5. Department of Epidemiology, University of Michigan, Ann Arbor.

Journal

Neurology

Summary

This paper from the University of Michigan examines the impact of adverse social exposome on survival in individuals with ALS. The study examined the association between the Area Deprivation Index (ADI), a measure of adverse social exposome, and ALS survival using a retrospective analysis of 1,085 patients diagnosed after January 1, 2012. The findings revealed that a higher ADI, indicating greater neighborhood disadvantage, was associated with significantly shorter survival times in ALS patients. The study highlights the importance of considering social factors in ALS care and the need for interventions to reduce health disparities. The authors recommend that further research is needed to understand the underlying mechanisms, which could influence ALS clinical care.

Link to Paper

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