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Baseline Estimates of Colorectal Cancer Screening Among Adults Aged 45 to 75 Years, Behavioral Risk Factor Surveillance System, 2022

Sallyann Coleman King, MD, MSc1,2; Jessica King, MPH1; Cheryll C. Thomas, MSPH1; Lisa C. Richardson, MD, MPH1 (View author affiliations)

Suggested citation for this article: King SC, King J, Thomas CC, Richardson LC. Baseline Estimates of Colorectal Cancer Screening Among Adults Aged 45 to 75 Years, Behavioral Risk Factor Surveillance System, 2022. Prev Chronic Dis 2025;22:250175. DOI: http://dx.doi.org/10.5888/pcd22.250175.

PEER REVIEWED

Summary

What is already known on this topic?

Colorectal cancer (CRC) screening allows for early detection and prevention of CRC. The starting age for CRC screening was lowered to 45 years in 2021.

What is added by this report?

We used the new screening recommendation and 2022 Behavioral Risk Factor Surveillance System data to present baseline estimates of newly eligible adults aged 45 to 49 who are up to date on CRC screening; approximately 2 in 3 such adults have never been screened for CRC.

What are the implications for public health practice?

Recommendations from health care professionals can increase CRC screening uptake for newly eligible adults.

Abstract

Colorectal cancer (CRC) screening allows for early detection and prevention through removal of polyps. In 2021, the US Preventive Services Task Force updated recommendations to screen adults aged 45 to 75 years. We analyzed 2022 Behavioral Risk Factor Surveillance System data to establish baseline prevalence estimates for those eligible for screening aged 45 to 75, including those aged 45 to 49 years who are newly eligible. Only 61.4% of adults aged 45 to 75 were up to date with CRC screening, below the Healthy People 2030 target (72.8%). Public health and clinical systems can prioritize identifying and screening adults not up to date on screening to reduce CRC risk.

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Objective

Colorectal cancer (CRC) is the fourth most common cause of cancer among men and women in the US (1). While screening provides the opportunity for early detection and prevention through the removal of polyps, many eligible people remain unscreened (2). Current recommendations support screening people aged 45 to 75 years to reduce the risk of CRC (3). Those who receive screening have been shown to have a lower risk of the disease (4,5). Understanding the characteristics of those who are not up to date with CRC screening may be important for creating new interventions and refining existing interventions that support screening uptake. We conducted this analysis by using the updated questions in the 2022 Behavioral Risk Factor Surveillance System (BRFSS) to establish baseline prevalence estimates for those eligible for screening aged 45 to 75 (including those aged 45-49 years who are newly eligible) based on changes in the US Preventive Services Task Force (USPSTF) recommendations in 2021 (3). The following test types were measured in our analysis: high-sensitivity guaiac fecal occult blood testing (gFOBT) annually, fecal immunohistochemical test (FIT) annually, stool DNA-FIT every 1 to 3 years, colonoscopy every 10 years, computed tomography (CT) colonography every 5 years, flexible sigmoidoscopy every 5 years, and flexible sigmoidoscopy with FIT every 10 years plus a FIT annually. We also assessed progress in achieving the Healthy People 2030 CRC screening target of having 72.8% of all age-eligible people screened for CRC (6).

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Methods

The BRFSS is an annual, state-based, random-digit-dialed telephone survey of the civilian, noninstitutionalized adult population aged 18 years or older (7). BRFSS collects information on demographic characteristics, health risk behaviors, preventive health practices, and health care access in the US. CRC screening questions are part of the rotating core of questions administered by all health departments during even years. In 2021, the questions for CRC screening were modified to align with the questions used in the National Health Interview Survey, including modifications in wording, number of questions, and inclusion of questions on CT colonography and Cologuard (Exact Sciences Corporation). We analyzed data from the 2022 BRFSS to examine screening prevalence among adults currently recommended for screening (adults aged 45-75 years) and assessed baseline prevalence for those aged 45 to 49 years who are newly recommended for screening in the 2021 USPSTF recommendation (3). We assessed selected variables on demographic characteristics and health care access, tabulated by 3-level variables on screening status (up to date on screening by any method; screened but not up to date; and never screened). People were considered to be up to date with CRC screening if they followed the USPSTF recommendation for CRC screening with any test type (3). Respondents who declined to answer or who answered "don't know/not sure" were excluded from analysis. Demographic variables analyzed were age (45-49, 50-64, 65-75 years), sex (male, female), race and ethnicity (Hispanic, non-Hispanic American Indian or Alaska Native, non-Hispanic Asian or Native Hawaiian Islander, non-Hispanic Black, non-Hispanic White, non-Hispanic "Other" race or multiracial), educational attainment (did not graduate from high school, graduated from high school, attended college or technical school, and graduated from college or technical school), annual household income (<$15,000, $15,000 to <$35,000, $35,000 to <$50,000, $50,000 to <$75,000, and ≥$75,000), and metropolitan or nonmetropolitan residence at the county level.

The BRFSS design weight handles nonresponse bias (7). We used SAS-callable SUDAAN version 9.4 (RTI International) to account for the complex sampling design. Data were weighted to the age, sex, and racial and ethnic distribution of each state's adult population by using intercensal estimates. Results were age-standardized to the 2000 US standard million population for groups aged 45 to 49, 50 to 64, and 65 to 74 years.

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Results

The overall response rate for the 2022 BRFSS was 45.1 %. Six in 10 (61.4%; 95% CI, 60.9%–61.8%) adults aged 45 to 75 years were up to date with CRC screening, accounting for almost 69.4 million people (Table). Of the adults aged 45 to 75 years, more had never been screened (32.3%) than screened but not up to date (6.3%). Of the 3 age groups, adults aged 65 to 75 years were the most likely to be up to date with screening (81.5%). Almost 30% (29.8%; 95% CI, 28.6%–31.0%) of those aged 45 to 49 years were up to date with screening. About 63% of women reported being up to date with CRC screening (62.8%; 95% CI, 62.1%–63.4%). Up-to-date screening for men was 60.0% (95% CI, 59.3%–60.6%). By race and ethnicity, 65.0% of non-Hispanic Black and 63.5% of non-Hispanic White adults reported up-to-date screening, compared with 52.4% of Hispanic adults. Screening prevalence was higher among adults who had higher educational attainment (67.2% [95% CI, 66.6%–67.9%] among those who graduated from college or technical school), had higher annual household income (67.2% [95% CI, 66.5%–67.8%] among those with an income of ≥$75,000), lived in a metropolitan area (61.9%; 95% CI, 61.4%–62.4%), reported having a health insurance plan (63.5%; 95% CI, 63.0%–63.9%), reported having a personal doctor (64.6%; 95% CI, 64.1%–65.1%), and had a routine checkup within the past year (66.4%; 95% CI, 65.8%–66.9%). Nearly one-third of women (30.6%; 95% CI, 30.0%–31.3%) and 34.1% (95% CI, 33.5%–34.7%) of men had never been screened for CRC. Although adults aged 45 to 49 years represent a small proportion of those eligible for screening in the US, almost two-thirds (65.7%; 95% CI, 64.5%–67.0%) had never been screened.

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Discussion

A previous report showed that the up-to-date CRC screening prevalence among adults 50 to 75 years was approximately 72% (2). While we cannot make direct comparisons because our data comprised adults starting at age 45 years, our data showed that 61.4% of adults aged 45 to 75 were up to date on CRC screening, indicating that concerted and continued efforts can help reach the Healthy People 2030 target of 72.8%. However, less than one-third of adults aged 45 to 49 years were up to date, and an estimated 28 million adults aged 45 to 75 years were never screened. Continued improvement will be needed to meet the Healthy People 2030 objective of 72.8% (6) for adults aged 45 to 75 years being up to date with CRC screening (6).

Clinical recommendations have consistently been shown to increase cancer screening uptake (8). These recommendations could help with the almost one-third of age-eligible adults and the two-thirds of adults aged 45 to 49 who have never been screened for CRC. Because completing even a single screening with colonoscopy or sigmoidoscopy can provide some benefit in reducing CRC risk (5,9), clinicians can discuss all appropriate screening options with newly eligible patients so that they are prepared to follow through now and at regular intervals in the future (10). The National Health Interview Survey showed that most adults who were not up to date with screening reported that they did not receive a recommendation from their clinician at their most recent annual visit (8).

Our findings are subject to several limitations. BRFSS data are self-reported, which may lead to reporting bias (over and under reporting). Participants are recruited through a random-digit-dialing system, which excludes institutionalized people and some members of the military. These groups may have different levels of CRC screening uptake due to different levels of accessing care or different levels of trust in the health care system. Finally, CRC screening includes many options and various screening intervals, which can be complicated and difficult to recall accurately.

The new baseline estimate in 2022 of only 61.4% of those aged 45 to 75 years reporting being up to date with CRC screening creates a challenge in reaching 2030 Healthy People goals. Twenty-eight million American adults aged 45 to 75 years reported never being screened for CRC; of those, 35.0% were aged 45 to 49 years. Clinicians, public health practitioners, community health organizations, and others can work together to reduce barriers and help to ensure that each patient visit with a clinician includes time to address CRC screening. This concerted effort can help to ensure that those who are eligible receive screening services that may affect their long-term health.

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Acknowledgments

The authors declare no potential conflicts of interest with respect to the research, authorship, or publication of this article. The authors received no external financial support for the research, authorship, or publication of this article. No copyrighted material, surveys, instruments, or tools were used in the research described in this article. The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention.

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Author Information

Corresponding Author: Sallyann Coleman King, MD, MSc, Division of Cancer Prevention and Control, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, 4770 Buford Hwy, Atlanta, GA 30341 (fjq9@cdc.gov).

Author Affiliations: 1Division of Cancer Prevention and Control, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia. 2US Public Health Service, Washington, DC.

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References

  1. Centers for Disease Control and Prevention, National Cancer Institute. United States cancer statistics: data visualizations. June 2022. Accessed June 3, 2025. www.cdc.gov/cancer/dataviz
  2. Richardson LC, King JB, Thomas CC, Richards TB, Dowling NF, Coleman King S. Adults who have never been screened for colorectal cancer, Behavioral Risk Factor Surveillance System, 2012 and 2020. Prev Chronic Dis. 2022;19(4):E21. PubMed doi:10.5888/pcd19.220001
  3. Davidson KW, Barry MJ, Mangione CM, Cabana M, Caughey AB, Davis EM, et al. . Screening for colorectal cancer: US Preventive Services Task Force recommendation statement. JAMA. 2021;325(19):1965–1977. PubMed doi:10.1001/jama.2021.6238
  4. Lee JK, Jensen CD, Levin TR, Zauber AG, Schottinger JE, Quinn VP, et al. . Long-term risk of colorectal cancer and related deaths after a colonoscopy with normal findings. JAMA Intern Med. 2019;179(2):153–160. PubMed doi:10.1001/jamainternmed.2018.5565
  5. Atkin W, Wooldrage K, Parkin DM, Kralj-Hans I, MacRae E, Shah U, et al. . Long term effects of once-only flexible sigmoidoscopy screening after 17 years of follow-up: the UK Flexible Sigmoidoscopy Screening randomised controlled trial. Lancet. 2017;389(10076):1299–1311. PubMed doi:10.1016/S0140-6736(17)30396-3
  6. Office of Disease Prevention and Health Promotion. Increase the proportion of adults who get screened for colorectal cancer - C-07. Healthy People 2030. Accessed March 21, 2025. https://odphp.health.gov/healthypeople/objectives-and-data/browse-objectives/cancer/increase-proportion-adults-who-get-screened-colorectal-cancer-c-07
  7. Center for Disease Control and Prevention. Behavioral Risk Factor Surveillance System. Last reviewed June 4, 2025. Accessed March 21, 2025. https://www.cdc.gov/brfss/index.html
  8. Baeker Bispo J, Bandi P, Jemal A, Islami F. Receipt of clinician recommendation for colorectal cancer screening among underscreened U.S. adults. Ann Intern Med. 2023;176(9):1985–1987. PubMed doi:10.7326/M23-1341
  9. Lee JK, Jensen CD, Levin TR, Zauber AG, Schottinger JE, Quinn VP, et al. . Long-term risk of colorectal cancer and related deaths after a colonoscopy with normal findings. JAMA Intern Med. 2019;179(2):153–160. PubMed doi:10.1001/jamainternmed.2018.5565
  10. Makaroff KE, Shergill J, Lauzon M, Khalil C, Ahluwalia SC, Spiegel BMR, et al. . Patient preferences for colorectal cancer screening tests in light of lowering the screening age to 45 years. Clin Gastroenterol Hepatol. 2023;21(2):520–531.e10. PubMed doi:10.1016/j.cgh.2022.07.012

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Table

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Table. Colorectal Cancer Screening, by Demographic Characteristics, Among Survey Respondents Aged 45 to 75 Years, Age-Standardized to US 2000 Standard Million Population, Behavioral Risk Factor Surveillance System, 2022
Characteristic Screened and up to datea Screened but not up to date Never screened
No.b Weighted no.c % (95% CI) No.b Weighted no.c % (95% CI) No.b Weighted no.c % (95% CI)
Total 152,617 69,383,246 61.4 (60.9–61.8) 15,276 6,912,665 6.3 (6.1–6.5) 49,300 28,326,502 32.3 (31.9–32.8)
Age, y
45–49 7,430 4,494,252 29.8 (28.6–31.0) 1,131 665,883 4.4 (3.9–5.0) 16,639 9,905,489 65.7 (64.5–67.0)
50–64 71,184 37,146,966 66.9 (66.3–67.6) 7,101 3,646,075 6.6 (6.3–6.9) 24,013 14,715,832 26.5 (25.9–27.1)
65–75 74,003 27,742,028 81.5 (80.8–82.1) 7,044 2,600,707 7.6 (7.3–8.0) 8,648 3,705,181 10.9 (10.4–11.4)
Sex
Male 70,265 32,855,903 60.0 (59.3–60.6) 6,603 3,163,611 6.0 (5.6–6.3) 24,452 14,706,371 34.1 (33.5–34.7)
Female 82,352 36,527, 343 62.8 (62.1–63.4) 8,673 3,749,054 6.6 (6.3–6.9) 24,848 13,620,131 30.6 (30.0–31.3)
Race and ethnicity
Hispanic 7,071 6,894,150 52.4 (50.6–54.1) 806 777,527 5.9 (5.1–6.8) 5,051 5,473,168 41.7 (40.0–43.4)
Non-Hispanic American Indian or Alaska Native 2,038 728,319 53.7 (49.3–58.0) 230 63,665 4.8 (3.5–6.7) 1,204 496,493 41.5 (37.3–45.8)
Non-Hispanic Asian or Native Hawaiian Islander 2,692 2,862,985 53.4 (50.2–56.5) 256 272,015 5.3 (4.0–6.9) 1,692 2,081,866 41.3 (38.3–44.4)
Non-Hispanic Black 11,923 8,413,031 65.0 (63.5–66.4) 859 620,920 5.0 (4.4–5.6) 3,996 3,257,386 30.1 (28.7–31.5)
Non-Hispanic White 122,850 47,149,588 63.5 (63.0–63.9) 12,413 4,802,221 6.8 (6.5–7.0) 34,808 15,421,667 29.8 (29.3–30.2)
Non-Hispanic “Other” race or multiracial 2,444 1,673,798 60.8 (57.5–64.0) 293 211,987 7.9 (5.9–10.5) 1,068 752,818 31.3 (28.5–34.3)
Education level
Did not graduate from high school 5,899 5,696,915 46.6 (44.8–48.5) 740 749,102 6.0 (5.2–7.0) 4,466 4,959,768 47.4 (45.6–49.2)
Graduated from high school 32,430 16,494,296 58.2 (57.2–59.1) 3,589 1,710,288 6.2 (5.8–6.6) 13,102 7,598,646 35.7 (34.7–36.6)
Attended college or technical school 42,791 22,276,097 62.8 (62.0–63.7) 4,462 2,197,668 6.5 (6.0–6.9) 13,300 8,018,756 30.7 (29.9–31.5)
Graduated from college or technical school 71,198 24,718,061 67.2 (66.6–67.9) 6,459 2,245,607 6.4 (6.0–6.7) 18,273 7,654,521 26.4 (25.8–27.0)
Annual household income, $
<15,000 6,622 3,274,572 51.8 (49.9–53.7) 979 405,526 6.7 (5.9–7.6) 3,486 2,116,888 41.5 (39.6–43.5)
15,000 to <35,000 24,210 11,019,227 53.9 (52.7–55.0) 2,930 1,320,788 6.6 (6.0–7.2) 9,549 5,790,075 39.5 (38.4–40.7)
35,000 to <50,000 15,838 6,568,178 58.2 (56.6–59.8) 1,765 710,105 6.5 (5.9–7.2) 4,898 2,669,320 35.3 (33.6–36.9)
50,000 to <75,000 22,805 9,327,911 63.2 (62.0–64.4) 2,257 907,721 6.2 (5.7–6.8) 6,227 3,137,356 30.6 (29.4–31.7)
≥75,000 58,806 27,546,973 67.2 (66.5–67.8) 4,794 2,347,583 5.8 (5.5–6.2) 17,639 9,889,429 27.0 (26.4–27.7)
Metropolitan or nonmetropolitan
Metro 109,262 58,426,583 61.9 (61.4–62.4) 10,417 5,660,463 6.2 (5.9–6.5) 34,121 23,608,333 31.9 (31.4–32.4)
Nonmetro 43,318 10,954,718 58.7 (57.8–59.6) 4,853 1,251,808 6.8 (6.4–7.3) 15,161 4,716,487 34.5 (33.6–35.4)
Have health plan
Yes 147,200 66,323,527 63.5 (63.0–63.9) 14,311 6,401,816 6.3 (6.1–6.6) 42,803 23,763,799 30.2 (29.8–30.7)
No 2,064 1,371,230 28.7 (26.0–31.6) 602 328,858 7.1 (4.8–10.4) 5,005 3,591,154 64.2 (61.3–66.9)
Have personal doctor
Yes 145,820 65,799,662 64.6 (64.1–65.1) 13,690 6,106,705 6.2 (5.9–6.4) 39,080 22,140,978 29.2 (28.8–29.7)
No 6,048 3,170,164 33.3 (31.8–34.8) 1,467 755,831 7.9 (7.0–8.9) 9,741 5,853,127 58.8 (57.3–60.4)
Last routine checkup
Never 153 81,394 18.0 (13.0–24.3) 47 27,842 7.1 (4.2–12.0) 568 342,469 74.9 (68.0–80.7)
Within past year 136,999 62,236,363 66.4 (65.8–66.9) 11,750 5,245,255 5.8 (5.5–6.0) 32,664 18,965,208 27.9 (27.4–28.4)
2 to <5 Years ago 13,542 6,203,889 46.8 (45.5–48.1) 2,576 1,157,080 8.8 (8.1–9.5) 10,032 5,814,278 44.4 (43.1–45.7)
≥5 Years ago 1,223 563,899 16.0 (14.3–17.8) 752 393,514 11.2 (9.4–13.3) 5,241 2,733,851 72.8 (70.5–75.1)

a Up to date with screening includes those screened by any of the screening tests recommended by US Preventive Services Task Force within the suggested screening interval (3): 1) high-sensitivity guaiac fecal occult blood testing annually, 2) fecal immunohistochemical test (FIT) annually, 3) stool DNA-FIT every 1 to 3 years, 4) colonoscopy every 10 years, 5) computed tomography colonography every 5 years, 6) flexible sigmoidoscopy every 5 years, or 7) flexible sigmoidoscopy with FIT every 10 years, plus FIT every year.
b Number who participated in the survey.
c Number who participated in the survey extrapolated to the US population.

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